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US Life Science Patents to Australian assignees, 2014
By Stuart Roberts, Senior Analyst, stuart@ndfresearch.com, +61 447 247 909
The US Patent Office issues new patents every Tuesday. Australian assignees generally get two or three healthcare and biotech-related patents a week. Here are the 133 US patents relevant to Australia's Life Sciences sector that issued in 2014, for an issuance rate of 2.3 patents per week.

US Patent 8,921,374

Title: Itraconazole compositions and dosage forms, and methods of using the same
Issued: 30 December 2014​
Assignee: Mayne Pharma (ASX: MYC)
Description: This patent covers an itraconazone formulation with improved bioavailability.

US Patent 8,921,309

Title: Lipopeptide compounds and their use
Issued: 30 December 2014​
Assignee: Uniquest Pty Ltd
Description: This patent covers a a modified version of the lipopeptide antiobiotic friulimicin with modified acyl side chains.

US Patent 8,921,306

Title: Nociceptin mimetics
Issued: 30 December 2014​
Assignee: University of Queensland
Description: This patent covers an improved version of nociceptin with better binding to its ligand, the opioid receptor-like-1 receptor.

US Patent 8,920,851

Title: Treatment of neurodegenerative diseases
Issued: 30 December 2014​
Assignee: Velacor Therapeutics
Description: This patent covers the use of selenium compounds to enhance the activity of phosphatase PP2A to inhibit phosphorylation of tau protein.

US Patent 8,920,806

Title: Method of modulating inflammatory response by downregulation of activin
Issued: 30 December 2014​
Assignee: Paranta Biosciences
Description: This patent covers antagonists to Actavin A as an anti-inflammatory target.

US Patent 8,920,803

Title: Immunotherapeutic method involving CD123 (IL-3R.alpha.) antibodies and immunostimulating complex
Issued: 30 December 2014​
Assignee: CSL Ltd (ASX: CSL) 
Description: This patent covers an anti-CD123 antibody adjuvanted by Iscomatrix for the treatment of hematoligic disorders.

US Patent 8,916,523

Title: VIP fragments and methods of use
Issued: 23 December 2014​
Assignee: Vectus Biosystems (ASX: VBS)
Description: This patent covers the use of vasoactive intestinal peptide (VIP) fragment in treating fibrosis and hypertension. 

US Patent 8,916,166

Title: Porphyromonas gingivalis polypeptides useful in the prevention of periodontal disease
Issued: 23 December 2014​
Assignee: ​Oral Health CRC
Description: This patent covers drug targets useful in eliminating P. gingivalis infection.

US Patent 8,912,225

Title: VEGF inhibition
Issued: 16 December 2014​
Assignee: PharmAust (ASX: PAA)
Description: This patent covers a formulation of albendazole which works through VEGF inhibition to treat ovarian cancer.

US Patent 8,911,997

Title: ​Mammalian cell culture medium
Issued: 16 December 2014​
Assignee: Queensland University of Technology
Description: This patent covers a combination of vitronectin and IGF Binding Protein useful for propagating keratinocytes.

US Patent 8,911,745

Title: Immunology treatment for biofilms
Issued: 16 December 2014​
Assignee: Oral Health CRC
Description: This patent covers a P. gingivalis vaccine.

US Patent 8,906,919

Title: Treatment of non-neuronal and non-myocardial cell, tissue and organ damage and associated pain with persistent sodium current blockers
Issued: 9 December 2014​
Assignee: Ozteo Pty Ltd
Description: This patent covers the use of sodium channel blockers in preventing tissue damage.

US Patent 8,906,912

Title: Anxiolytic compounds
Issued: 9 December 2014​
Assignee: Bionomics (ASX: BNO)
Description: This patent covers a GABA.A receptor agonist with better properties than existing drugs for the treatment of anxiety.

US Patent 8,906,279

Title: Humanized antibodies with anti-tumor activity
Issued: 2 December 2014​
Assignee: Teva Pharmaceuticals Australia
Description: This patent covers an anti-cancer antibody.

US Patent 8,895,698

Title: Binding partners of antibodies specific for dendritic cell antigens
Issued: 25 November 2014​
Assignee: Mater Hospital Brisbane
Description: This patent covers epitopes on dendritic cells useful as immunomodulatory targets.

US Patent 8,895,019

Title: Biofilm treatment
Issued: 25 November 2014​
Assignee: ​Oral Health CRC
Description: This patent covers drugs to treat P. gingivalis infection.

US Patent 8,889,695

Title: Quinazolinone compounds
Issued: 18 November 2014​
Assignee: Prana Biotechnology (ASX: PBT)
Description: This patent covers heterocyclic compounds useful in the treatment of Parkinson's Disease.

US Patent 8,883,015

Title: Patch production
Issued: 11 November 2014​
Assignee: University of Queensland
Description: This patent covers methods of creating a microneedle patch for drug and vaccine delivery.

US Patent 8,877,727

Title: Delivery of dsRNA to arthropods
Issued: 4 November 2014​
Assignee: Commonwealth Scientific and Industrial Research Organisation
Description: This patent covers a gene silencing method using double-stranded RNA.

US Patent 8,877,243

Title: Cross-linked polysaccharide composition
Issued: 4 November 2014​
Assignee:  Ultraceuticals
Description: This patent covers cross-linked hyaluronic acid gels with improved degradation characteristics.

US Patent 8,871,709

Title: Synthetic chimeric proteins comprising epidermal growth factor and vitronectin
Issued: 28 October 2014
Assignee: Queensland University of Technology
Description: This patent recombinant proteins combining elements of IGF-I and vitronectin, for use in wound repair. 

US Patent 8,871,272

Title: Layered nanoparticles
Issued: 28 October 2014​
Assignee: ​Australian Nuclear Science & Technology Organisation
Description: This patent covers core-shell ceramic nanoparticles for drug delivery.​

US Patent 8,871,272

Title: Probiotic storage and delivery
Issued: 28 October 2014​
Assignee: Commonwealth Scientific and Industrial Research Organisation
Description: This patent covers a method of encapsulating probiotic bacteria in milk proteins and a starch or sugar in order to enable better gastrointestinal delivery.

US Patent 8,871,213

Title: Prevention, treatment and diagnosis of P. gingivalis infection
Issued: 28 October 2014​
Assignee: Oral Health CRC
Description: This patent covers a P. gingivalis vaccine.

US Patent 8,865,736

Title: Antibacterial agents
Issued: 21 October 2014​
Assignee: Biota
Description: This patent covers substituted benzamides and pyridylamides with antibacterial activity.

US Patent 8,859,627

 Title: Anti-microbial composition
Issued: 14 October 2014​
Assignee: Wild Child
Description: This patent covers an anti-microbial composition of farnesol and cetrimide.

US Patent 8,858,951

Title: Compositions for eliciting an immune response
Issued: 14 October 2014​
Assignee: University of Queensland
Description: This patent covers a DNA vaccine that works via the ubiquitin-proteosome pathway.

US Patent 8,858,939

Title: Ectopic pregnancy treatment
Issued: 14 October 2014​
Assignee: Monash University
Description: This patent covers the combination of  gefitinib and methotrexate in treating ectopic pregnancy.

US Patent 8,252,641

Title: Polymer microgel beads and preparative method thereof
Issued: 7 October 2014​
Assignee: University of Sydney
Description: This patent covers polymer microgel beads incorporating nanomagnetic particles, useful in applications such the hyperthermic treatment of tissue.

​US Patent 8,846,026

Title: Composition comprising immunogenic microparticles
Issued: 30 September 2014​
Assignee: PX BioSolutions
Description: This patent covers virus-sized microparticles, useful as vaccine material.

US Patent 8,841,420

Title: Synthetic peptide constructs for the diagnosis and treatment of periodontis associated with Porphyromonas gingivalis
Issued: 23 September 2014​
Assignee: University of Melbourne
Description: This patent covers a P. gingivalis vaccine.​

US Patent 8,841,351

Title: Polymeric topical compositions
Issued: 23 September 2014​
Assignee: Stiefel Research Australia
Description: This patent covers a rapid-drying antibacterial hand rub.

US Patent 8,841,342

Title: Carrier
Issued: 23 September 2014​
Assignee: Vital Health Sciences (Simon West)
Description: This patent covers the use of phosphorylated Vitamin E to improve the water solubility of pharmaceuticals. 

US Patent 8,841,254

Title: Method for treatment of anxiety
Issued: 23 September 2014​
Assignee: Florey Institute of Neuroscience and Mental Health
Description: This patent covers the use of H3 relaxin and analogues thereof in the treatment of anxiety.

US Patent 8,835,629

 Title: Anti-cancer agents
Issued: 16 September 2014​
Assignee: Walter and Eliza Hall Institute
Description: This patent covers analogues of Naamidine A, an imidazole alkaloid extracted from Leucetta sponges.

US Patent 8,835,609

Title: Antigen binding sites to non-functional oligomeric P2X7 receptors and methods of use thereof
Issued: 16 September 2014​
Assignee: Biosceptre International
Description:  This patent covers the targets for various antibodies to P2X7 , useful in inducing apoptosis in cancer cells.

US Patent 8,835,478

Title: Treatment for cancer
Issued: 16 September 2014​
Assignee: PharmAust (ASX: PAA)
Description: This patent covers the combination of albendazole and paclitaxel in treating cancer. 

US Patent 8,834,872

Title: Uses of antibodies
Issued: 16 September 2014​
Assignee: Antony Scammell
Description: This patent covers antibodies to gastrointestinal cancer, administered in milk or egg products for better targeting.

US Patent 8,828,933

Title: Mutant tat proteins and uses thereof
Issued: 9 September 2014​
Assignee: Queensland Institute of Medical Research
Description: This protein covers mutants of the HIV protein tat, useful in inhibiting multiple steps in the HIV-1 replication cycle.

US Patent 8,828,435

Title: Buccal delivery system
Issued: 9 September 2014​
Assignee: Lingual Consegna Pty Ltd
Description: This patent covers a buccal drug delivery system.

US Patent 8,828,409

Title: Vaccine comprising recombinant CLPP protein of Streptococcus pneumoniae
Issued: 9 September 2014​
Assignee: ​Adelaide Research & Innovation (50%), Sungkyunkwan University (50%)
Description: This patent covers recombinant caseinolytic protease P as a vaccine for S. pneumoniae.

US Patent 8,822,644

Title: Method of treating cancer comprising a VEGF-B antagonist
Issued: 2 September 2014​
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers antibodies for VEGF-B.

US Patent 8,822,509

Title: Pain-relieving compositions and uses therefor
Issued: 2 September 2014​
Assignee: University of Queensland
Description: This patent covers nitric oxide donors for the treatnenbt of diabetic neuropathy.

US Patent 8,822,416

Title: Topical analgesic composition
Issued: 2 September 2014​
Assignee: Animal Ethics Pty Ltd
Description: This patent covers  a topical anesthetic for applications such as mulesing of sheep.​

US Patent 8,822,409

Title: Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith
Issued: 2 September 2014​
Assignee: Phylogica (ASX: PYC)
Description: This patent covers peptides to inhibit AP-1 signalling.

US Patent 8,815,936

Title: Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders
Issued: 26 August 2014​
Assignee: NAD Life
Description: This patent covers the combination of resveratol, a chelating agent and an anti-oxidant to prevent oxidative stress.

US Patent 8,815,298

Title: Therapeutic composition comprising honey or a honey derivative
Issued: 26 August 2014​
Assignee: Medihoney Pty Ltd
Description: This patent covers a formulation of honey suitable for wound care.

US Patent 8,815,291

Title: Particles comprising a releasable dopant therein
Issued: 26 August 2014​
Assignee: Australian Nuclear Science & Technology Organisation
Description:  This patent covers a method to include a dopant, such as a hydrophobic material, into solid or gel particles without the use of toxic solvents.

US Patent 8,809,386

Title: Use of dynamin ring stabilizers
Issued: 19 August 2014​
Assignee: Children's Medical Research Institute (50%), MassGeneral (US, 50%)
Description: This patent covers drugs that can stablise dynamin, an enzyme that helps  receptor-mediated endocytosis, and thereby treat kidney disease.

US Patent 8,809,301

Title: Surgical hydrogel
Issued: 19 August 2014​
Assignee: Adelaide Research & Innovation (33%), Robinson Squidgel Ltd (NZ, 33%), University of Otago (NZ, 33%)
Description: The patent covers a gel useful in reducing post-surgery sinus scarring, where the actives come from polymers found in squid and crab shell.

US Patent 8,808,751

Title: Methods for the preparation of biologically active compounds in nanoparticulate form
Issued: 19 August 2014​
Assignee: iCeutica
Description: This patent covers a method for dry-milling of pharmaceuticals to produce drug nanoparticles.

US Patent 8,808,716

Title: Topical foam composition
Issued: 19 August 2014​
Assignee: Stiefel Research Australia
Description: This patent covers an oil in water emulsion aerosol foam suitable for treating acute skin conditions, particularly acne and psoriasis.

US Patent 8,808,706

Title: Arthrospira-based compositions and uses thereof
Issued: 19 August 2014​
Assignee: Biovite Australia
Description: This patent covers a physiologically stressed version of the blue-green algae Arthrospira useful as an antibiotic.

US Patent 8,808,692

Title: Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
Issued: 19 August 2014
Assignee:  CSL Ltd (ASX: CSL) 
Description: This patent covers the combination of antibodies plus saponin derivatives as an adjuvant.

US Patent 8,807,861

Title: Spreading implement
Issued: 19 August 2014​
Assignee: Acrux (ASX: ACR)
Description: ​This patent covers the delivery system for Acrux's transdermal testosterone.

US Patent 8,802,840

Title: Bicyclic nucleosides and nucleotides as therapeutic agents
Issued: 12 August 2014​
Assignee: Biota
Description: This patent covers bicyclic nucleosides and nucleotides for the treatmet of Hepatitis C infection.

US Patent 8,802,634

Title: CD40-L Inhibitory Peptides
Issued: 12 August 2014​
Assignee: Phylogica (ASX: PYC)
Description: This patent covers an inhibitor to CD-40 ligand, useful as an anti-inflammatory.

US Patent 8,802,625

Title: Methods for promoting organ development
Issued: 12 August 2014​
Assignee: Kintan Pty Ltd
Description: This patent covers the use of colony stimulating factor-1 protein (CSF-1) in promoting growth in premature-birthed warm blooded animals. ​

US Patent 8,802,408

Title: Process for preparing nutritional, therapeutic or organoleptic products from crude glycerol
Issued: 12 August 2014​
Assignee: Bio Processing Australia
Description: This patent covers the use of crude glycerol to grow yeast.

US Patent 8,802,135

Title: Delivery system for remote treatment of an animal
Issued: 12 August 2014​
Assignee: Smartvet Pty Ltd
Description: This patent covers a gun to deliver doses to an animal remotely.

US Patent 8,802,116

Title: Poloxamer emulsion preparations
Issued: 12 August 2014​
Assignee: Novasel Pty Ltd (Steen Jorsal)
Description: This patent covers a microemulsion delivery systems for tea tree oil that does not require high temperature for  .

US Patent 8,796,273

Title: Compound for the treatment of enteroviruses
Issued: 5 August 2014​
Assignee: Biota
Description: This patent covers small molecules for the treatment of enterovirus infection. 

US Patent 8,796,225

Title: Regulation of immune responses by modulation of the function of antigen presenting cells
Issued: 5 August 2014​
Assignee: Invion (ASX: IVX)
Description: This patent covers chaperonin 10 polypeptides, useful for modulating cell surface expression of MHC molecules.

US Patent 8,790,909

Title: Strains of Helicobacter pylori and uses thereof
Issued: 29 July 2014​
Assignee: Ondek
Description:  This patent covers a safe strain of H. pylori as a tool for ​biological delivery vehicle for peptides.

US Patent 8,790,889

Title: Neuronal stimulation
Issued: 29 July 2014​
Assignee: University of Queensland
Description: This patent covers the production of adult hippocampal precursors bynorepinephrine in neurosphere-forming media.

US Patent 8,785,478

Title: Viral polymerase inhibitors
Issued: 22 July 2014​
Assignee: Biota
Description: This patent covers Hepatitis C virus polymerase inhibitors.

US Patent 8,785,140

Title: Cd4+ Cd25+ T-cells activated to a specific antigen
Issued: 22 July 2014​
Assignee: University of New South Wales
Description: This patent covers methods to grow regulatory T cells to a specific antigen to promote immune tolerance.

US Patent 8,784,878

Title: Transdermal delivery rate control using amorphous pharmaceutical compositions
Issued: 22 July 2014
​Assignee: Acrux (ASX: ACR)
Description: This patent covers the use of dermal penetration enhancers to control the rate of transdermal drug delivery.

US Patent 8,784,831

Title: P. gingivalis antigenic composition
Issued: 22 July 2014​
Assignee: CSL Ltd (ASX: CSL), University of Melbourne (50%)
Description: This patent covers antigenic peptides for use in a P. gingivalis vaccine.

US Patent 8,779,107

Title: Composition for targeting dendritic cells
Issued: 15 July 2014​
Assignee: Lipotek (50%), GSK (50%)
Description: This patent covers single domain antibodies to DC-SIGN, a dendritic cell antigen, for delivery of vaccine material to the dendritic cells.

US Patent 8,778,400

Title: Nanoparticle-stabilized capsule formulation for treatment of inflammation
Issued: 15 July 2014​
Assignee: University of South Australia
Description: This patent covers a nanoparticle-stabilised capsule formulation of celecoxib, which improves the drug;s bioavailability. 

US Patent 8,778,300

Title: Method of forming an injectable radioactive composition of a carbon encapsulated radioactive particulate
Issued: 15 July 2014​
Assignee: Australian National University
Description: This patent covers an improved radioactive composite product for diagnostic imaging.

US Patent 8,772,013

Title: Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells
Issued: 8 July 2014​
Assignee: EnGeneIC
Description:  This patent covers drug delivery using EnGeneIC's 'minicells'.

US Patent 8,771,764

Title: Composition and method for improving vascular health
Issued: 8 July 2014​
Assignee: Commonwealth Scientific and Industrial Research Organisation (50%), Malaysian Palm Oil Board (Malaysia, 50%)
Description: This patent covers palm oil extracts useful for vasorelaxation.

US Patent 8,771,739

Title: Pharmaceutical compositions for poorly soluble drugs
Issued: 8 July 2014​
Assignee: Mayne Pharma (ASX: MYC)
Description: This patent covers the use of hydroxypropyl methylcellulose phthalate to improve drug water solubility.

US Patent 8,771,701

Title: Compositions for immunotherapy and uses thereof
Issued: 8 July 2014​
Assignee: Burnet Institute
Description: This patent application covers a method of pulsing dendritic cells with a combination of antigen and mannose.

US Patent 8,765,812

Title: Therapeutic compounds
Issued: 1 July 2014​
Assignee: Fibrotech Therapeutics
Description: This patent covers a TGF-beta inhibitor for the treatment of fibrotic conditions.

US Patent 8,765,700

Title: Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions
Issued: 1 July 2014​
Assignee: Antisense Therapeutics (ASX: ANP)
Description: This patent covers an  antisense compound to VLA-4 for the treatment of asthma.

US Patent 8,765,677

Title: Omega conotoxin peptides
Issued: 1 July 2014​
Assignee: University of Queensland (50%), University of Sydney (50%)
Description: This patent covers peptides from cone shells for the treatment of neuropathic pain.

US Patent 8,765,183

Title: Polymer microgel beads
Issued: 1 July 2014​
Assignee: University of Sydney
Description: This patent covers polymer microgel beads incorporating nanomagnetic particles, useful in applications such the hyperthermic treatment of tissue.

US Patent 8,765,163

Title: Biocompatible material and uses thereof
Issued: 1 July 2014
​Assignee: University of Sydney
Description: This patent covers doped Hardystonite for tissue regeneration.

US Patent 8,765,144

Title: Antigenic complex for the diagnosis and treatment of Porphyromonas gingivalis infection
Issued: 1 July 2014​
Assignee: University of Melbourne
Description: This patent covers a P. gingivalis vaccine.​

US Patent 8,759,286

Title: Pharmaceutical compositions comprising a VEGF-D polypeptide
Issued: 24 June 2014​
Assignee: ​Opthea (ASX: OPT)
Description: This patent covers the composition of matter of VEGF-D.

US Patent 8,758,728

Title: Foamable suspension gel
Issued: 24 June 2014​
Assignee: Stiefel Research Australia
Description: This patent covers a gel for transdermal drug delivery.

US Patent 8,748,406

Title: Preventive for adhesion following abdominal surgery
Issued: 10 June 2014​
Assignee: Cellmid (ASX: CDY)
Description: This patent covers the use of midkine to prevent post-surgical intraperitoneal adhesions.

US Patent 8,747,830

Title: Wound repair composition and method
Issued: 10 June 2014
​Assignee: Queensland University of Technology
Description: This patent covers a bisphosphonate matrix metalloproteinase inhibitor for wound care.

US Patent 8,741,970

Title: Composition and method for the enhancement of the efficacy of drugs
Issued: 3 June 2014​
Assignee: Alchemia (ASX: ACL)
Description: This patent covers the use of hyaluronanic acid as a chemopotentiator in chemotherapy.

US Patent 8,741,296

Title: Adenocarcinoma specific antibody SAM-6, and uses thereof
Issued: 3 June 2014​
Assignee: Patrys (ASX: PAB)
Description: This patent covers an antibody to the cancer target SAM-6.

US Patent 8,735,566

Title: Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
Issued: 27 May 2014​
Assignee: EnGeneIC
Description: This patent covers 'minicells', which are bacteria where functional nucleic acids can be packaged into the cells without the use of plasmids.

US Patent 8,735,173

Title: Multiplex screening for lysosomal storage disorders (LSDS)
Issued: 27 May 2014
​Assignee: Women's and Children's Hospital, Adelaide
Description: This patent covers methods to identify LSD enzymes in an automated multiplex assay.

US Patent 8,729,020

Title: Methods for the treatment of aortic fibrosis with VIP fragments
Issued: 20 May 2014​
Assignee: Vectus Biosystems (ASX: VBS)
Description: This patent covers the use of vasoactive intestinal peptide (VIP) fragment in treating aortic fibrosis. 

US Patent 8,728,512

Title: Treatment and composition for wound healing
Issued: 20 May 2014​
Assignee: Professor Christopher Jackson
Description: This patent covers the use of Activated Protein C in wound healing.

US Patent 8,722,675

Title: Method of treatment or prophylaxis
Issued: 13 May 2014​
Assignee: Spinifex Pharmaceuticals
Description: This patent covers​ angiotensin II type 2 receptor antagonists for the treatment of neuropathic pain.

US Patent 8,722,634

Title: Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
Issued: 13 May 2014​
Assignee:  Garvan Institute of Medical Research (50%), Shanghai Institute of Materia Medica, Chinese Academy of Sciences (China, 50%) 
Description: This patent covers extracts from the bitter melon plant, useful among other things as a glucose transporter.

US Patent 8,722,036

Title: Methods for treating malignancies using coxsackieviruses
Issued: 13 May 2014​
Assignee: Viralytics (ASX: VLA)
Description: This patent covers the mechanism of action of Viralytics' onclytic virus.

US Patent 8,716,222

Title: Methods and compositions for promoting organ development
Issued: 6 May 2014​
Assignee: Kintan Pty Ltd
Description: This patent covers the use of colony stimulating factor-1 protein (CSF-1) in promoting growth in premature-birthed warm blooded animals.

US Patent 8,715,724

Title: Tabletting process
Issued: 6 May 2014​
Assignee: Mayne Pharma (ASX: MYC)
Description: This patent covers the use of anti-static agents in tabletting drugs.

US Patent 8,710,015

Title: Tropoelastin derivatives
Issued: 29 April 2014​
Assignee: University of Sydney
Description: This patent covers synthetic version of the elastin protein, useful in skin repair.

US Patent 8,709,486

Title: Administrable compositions
Issued: 29 April 2014​
Assignee: University of Sydney
Description: This patent covers a method of keeping particulate material dispersed in its liquid carrier, which is particularly useful in the administration of contrast agents.

US Patent 8,709,425

Title: Antibodies to non-functional P2X7 receptor
Issued: 29 April 2014​
Assignee: Biosceptre International
Description: This patent covers antibodies to P2X7 , useful in inducing apoptosis in cancer cells.

US Patent 8,703,147

Title: Methods and compositions for treating and preventing malaria
Issued: 22 April 2014
Assignee: Walter and Eliza Hall Institute
Description: This patent covers a malaria vaccine made from an erythrocyte binding antigen from  a strain of Plasmodium falciparum.

US Patent 8,703,116

Title: Modified macromolecule
Issued: 22 April 2014
Assignee: Starpharma (ASX: SPL)
Description: This patent covers the combination of dendrimers with polyethelene glycol for longer half-life.

US Patent 8,697,702

Title: Method of optimizing the treatment of Philadelphia-positive leukemia with imatinib mesylate
Issued: 15 April 2014​
Assignee: Medvet Science Pty Ltd (50%), Novartis (Switerland, 50%) 
Description: This patent covers a method of optimising Gleevec treatment by measuring octamer binding protein activity. 

US Patent 8,697,678

Title: Anaesthetic formulation
Issued: 15 April 2014​
Assignee: Drawbridge Pharmaceuticals
Description: This patent a clear aqueous solution of the neuroactive steroid anaesthetic Alphaxalone.

US Patent 8,697,145

Title: Substances having body mass redistribution properties
Issued: 15 April 2014​
Assignee: Horizon Science Pty Ltd (David Kannar and Barry Kitchen)
Description: This patent covers a polyphenol-containing extract of molasses that treats obesity through inhibition of ACE. 

US Patent 8,691,967

Title: Multiple promoter expression cassettes for simultaneous delivery of RNAi agents
Issued: 8 April 2014​
Assignee: Benitec (ASX: BLT)
Description: This patent covers expression cassettes for delivery of double-stranded RNA.

US Patent 8,691,963

Title: Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells
Issued: 8 April 2014​
Assignee: EnGeneIC
Description: This patent covers the use of minicells in the treatment of cancer, in combination with chemotherapy.

US Patent 8,691,765

Title: Metallothionein based neuronal therapeutic and therapeutic methods
Issued: 8 April 2014​
Assignee: University of Tasmania
Description: This patent covers the use of metallothionein IIA for neuroprotection  and neuroregeneration.

US Patent 8,686,110

Title: Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same
Issued: 1 April 2014​
Assignee: Walter and Eliza Hall Institute
Description: This patent covers proteins from the Bcl-2 superfamily suitable for inducing apoptosis in cancer cells.

US Patent 8,685,473

Title: Pawpaw and/or peach derived composition
Issued: 1 April 2014​
Assignee: Phoenix Eagle
Description: This patent covers actives from Carica papaya useful in varuious indications including skin disorders.

US Patent 8,680,141

Title: Spiroketals
Issued: 25 March 2014​
Assignee: EcoBiotics
Description: This patent covers a natural product originally derived from Cinnamomum laubatii and useful as an anti-infective.

US Patent 8,673,872

Title: Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA
Issued: 18 March 2014​
Assignee: University of Western Australia
Description: This patent covers an microRNA-based EGFR inhibitor.

US Patent 8,673,586

Title: Compounds that interact with kinases
Issued: 18 March 2014​
Assignee: Alchemia (ASX: ACL)
Description: This patent covers a suite of kinase inhibitors.

US Patent 8,673,367

Title: Nano silver-zinc oxide composition
Issued: 18 March 2014​
Assignee: Polymers CRC
Description: This patent covers a silver-zinc formation with anti-microbial properties.

US Patent 8,673,363

Title: Dental mineralization
Issued: 18 March 2014​
Assignee: University of Melbourne
Description: This protein covers the use of a bleaching gel with amorphous calcium phosphate in improving dental mineralisation.

US Patent 8,673,361

Title: Cytokine modulating composition
Issued: 18 March 2014​
Assignee: Cambridge Scientific Pty Ltd (Maud Eijkenboom)​
Description: This patent covers the use of denatured plasma plus a metal in inhibiting cytokine activity.

US Patent 8,673,305

Title: Methods of treatment with antibodies against the extracellular loops of C5aR
Issued: 18 March 2014​
Assignee: G2 Therapies
Description: This patent covers Complement C5a receptors antibodies  useful to treat inflammatory disorders.

US Patent 8,669,280

Title: Antiviral compounds and methods
Issued: 11 March 2014​
Assignee: Biotron (ASX: BIT)
Description: This patent covers various substituted acylguanidines for used as anti-virals.

US Patent 8,669,101

Title: Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
Issued: 11 March 2014​
Assignee: EnGeneIC
Description: : This patent covers the use of minicells in the treatment of cancer, in combination with chemotherapy.

US Patent 8,653,236

Title: Therapeutic agents
Issued: 18 February 2014​
Assignee: Inter-K Pty Ltd
Description: This patent covers a DNA transposase from Brevibacterium linens with anti-cancer properties. 

US Patent 8,652,511

Title: Transdermal delivery patch
Issued: 18 February 2014​
Assignee: Phosphagenics (ASX: POH)
Description: This patent covers a matrix patch for drug delivery.

US Patent 8,652,473

Title: Antibodies to EGF receptor epitope peptides and uses thereof
Issued: 18 February 2014​
Assignee: Commonwealth Scientific and Industrial Research Organization (33%), Ludwig Institute for Cancer Research (US, 33%), Massachusetts Institute of Technology (US, 33%)
Description: This patent covers anti-EGFR antibodies.

US Patent 8,642,731

Title: Porphyromonas gingivalis polypeptides and nucleotides
Issued:  4 February 2014
Assignee: CSL Ltd (ASX: CSL) (50%), University of Melbourne (50%)
Description: : This patent covers a P. gingivalis vaccine.

US Patent 8,642,631

Title: Methods of treating mammals with eustachian tube dysfunctions
Issued: 4 February 2014​
Assignee:​ University of Melbourne
Description: This patent covers the use of betahistine in treating disorders such as otitis media.

US Patent 8,637,262

Title: Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
Issued: 28 January 2014​
Assignee: Opthea (ASX: OPT)
Description: This patent covers antibodies to VEGF-C.

US Patent 8,637,051

Title: Compositions and methods for treatment of mucosal infections
Issued: 28 January 2014​
Assignee: Hunter Immunology
Description: This patent covers the use of respiratory tract bacteria with lactic acid bacteria to provide protracted protection against mucosal infection.

US Patent 8,637,025

Title: Composition and method for the treatment and prevention of enteric bacterial infections
Issued: 28 January 2014​
Assignee: Immuron (ASX: IMC)
Description: This patent covers hyperimmunes to enteric bacteria from vaccines comprising one or more cell wall antigens.

US Patent 8,637,016

Title: EphA3 antibodies for the treatment of solid tumors
Issued: 28 January 2014​
Assignee: Monash University (33%), KaloBios Pharmaceuticals (US, 33%), Ludwig Institute for Cancer Research (US, 33%) 
 Description: This patent covers antibodies to EphA3, a receptor tyrosine kinase known as a cancer target. 

US Patent 8,629,318

Title: Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation
Issued: 14 January 2014​
Assignee: University of Sydney
Description: This patent covers an animal model for detecting cytochrome P450 toxicity.

US Patent 8,629,241

Title: Alpha helical mimics, their uses and methods for their production
Issued: 14 January 2014​
Assignee: University of Queensland
Description: This patent covers short chain peptides that form an alpha helicial conformation, useful for developing biomimetics.

US Patent 8,628,761

Title: Biodegradable polyurethane/urea compositions
Issued: 14 January 2014​
Assignee: Polynovo (ASX: PNV)
Description: This patent covers a biodegradable polymer useful in tissue repair.

US Patent 8,624,025

Title: Antiviral agents
Issued: 7 January 2014​
Assignee: Biota
Description: This patent covers small molecules to treat human rhinovirus infection.

US Patent 8,623,354

Title: Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
Issued: 7 January 2014​
Assignee: Alchemia (ASX: ACL)
Description: This patent covers the use of hyaluronic acid in combination of anti-cancer antibodies. 

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