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US Life Science Patents to Australian assignees, 2015
By Stuart Roberts, Senior Analyst, stuart@ndfresearch.com, +61 447 247 909
The US Patent Office issues new patents every Tuesday. Australian assignees generally get two or three healthcare and biotech-related patents a week. Here are the 136 US patents relevant to Australia's Life Sciences sector that issued between 6 January 2015 and 29 December 2015, for an issuance rate of 2.6 per week. For patents issued in the last twelve months click here.

US Patent 9,221,799

Title: Anti-cancer agents
Issued: 29 December 2015
Assignee: ​Walter and Eliza Hall Institute
Description:  This patent covers analogus of the marine alkaloid naamidine A, which is an antagonist of the Epidermal Growth Factor Receptor.

US Patent 9,220,928

Title: Plant extracts from Acronychia species and their use
Issued: 29 December 2015
Assignee: EcoBiotics
Description: This patent covers natural products derived from a rainforest treet native to north Queensland called the lemon aspen (Acronychia acidula).

US Patent 9,220,806

Title: Biocompatible material and uses thereof
Issued: 29 December 2015
Assignee: University of Sydney
Description: This patent covers a biocompatible ceramic made of doped calcium zinc silicate and a metal oxide useful in tissue regeneration. 

US Patent 9,220,724

Title: MicroRNA-based approach to treating malignant pleural mesothelioma​
Issued: 29 December 2015
Assignee: Asbestos Diseases Research Institute
Description: This patent covers microRNA mimics, corresponding to the miR-15/107 family potentially useful in the treatment of mesothelioma.

US Patent 9,220,678

Title: Coating method
Issued: 29 December 2015
Assignee: University of Queensland
Description: This patent covers a method of coating bioactives onto projections from a patch.

US Patent 9,211,331

Title: Mineral based composition and methods of use
Issued: 15 December 2015
Assignee: Tuffrock
Description: This patent covers natural alumino-silicate minerals used in animal husbandry which have been irradiated to improve bioavailability.

US Patent 9,211,329

Title: Method of treating inflammatory bowel disease
Issued: 15 December 2015
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers the use of GM-CSF inhibitors in the treatment of inflammatory bowel disease.

US Patent 9,211,237

Title: Film foaming hydroalcoholic foam​
Issued: 15 December 2015
Assignee: Stiefel Research Australia
Description: This patent covers a water-resistant sunscreen.

US Patent 9,206,171

Title: 6-{2 -[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzi- soxazole bis-dihydrogenphosphate salt (1:2)
Issued: 8 December 2015
Assignee: Biota
Description: This patent covers composition of matter over Biota's human rhinovirus drug.

US Patent 9,205,121

Title: Echinacea formulation
Issued: 8 December 2015
Assignee: Integria Healthcare
Description: This patent covers a formulation of Echinacea that better metabolise the alkylamides that can  macrophage immune responses.

US Patent 9,200,020

Title: 6-oxopurine phosphoribosyltransferase inhibitors
Issued: 1 December 2015
Assignee: University of Queensland (50%), Institute of Organic Chemistry and Biochemistry (Czechia, 50%)
Description: This patent covers a potential new malaria drug.

US Patent 9,199,976

Title: Haematopoietic-prostaglandin D2 synthase inhibitors
Issued: 1 December 2015
Assignee: University of Queensland
Description: This patent covers a prostaglandin inhibitor that would work without the side effects of cyclooxygenase inhibition.​

US Patent 9,193,716

Title: S1P receptors modulators and their use thereof
Issued: 24 November 2015
Assignee: Akaal Pharma
Description: This patent covers a Sphingosine 1-phosphate (S1P)  modulator for anti-inflammatory applications.

US Patent 9,186,404

Title: Brain, spinal and nerve injury treatment
Issued: 17 November 2015
Assignee: Eustralis Pharmaceuticals
Description: This patent covers​ Substance P receptor antagonists.

US Patent 9,186,321

Title: Oral spray formulations and methods for administration of sildenafil
Issued: 17 November 2015
Assignee: Suda Ltd (ASX: SUD)
Description: This patent covers​ delivery of Viagra via a buccal spray.

US Patent 9,181,320

Title: Peptides for generating an antibody selectively binding to a non-ATP-binding P2X7 receptor but not to an ATP-binding P2X7 receptor
Issued: 10 November 2015
Assignee: ​Biosceptre International
Description: This patent covers​ antibodies to P2X7 receptors where those receptors are not functional.

US Patent 9,180,194

Title: Method and composition for transdermal drug delivery
Issued: 10 November 2015
Assignee: ​Acrux (ASX: ACR)
Description: This patent covers​ Acrux's Axiron testosterone spray formulation.

US Patent 9,175,279

Title: Method of purifying factor VII and/or factor VIIa
Issued: 3 November 2015
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers​ a new method for making Factor VII.

US Patent 9,174,982

Title: Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Issued: 3 November 2015
Assignee: ​Walter and Eliza Hall Institute (33%), AbbVie (US, 33%), Genentech (US, 33%)
Description: This patent covers small molecules that inhibit ​anti-apoptotic Bcl-2 proteins.

US Patent 9,173,911

Title: Method for producing vegetable cell sap concentrate and means for the production thereof
Issued: 3 November 2015
Assignee: Solagran (50%), ​SibEX (Russia, 50%)
Description: This patent covers the use of ​liquefied carbonic acid to extract vegetable sap.

US Patent 9,173,866

Title: Compositions and products containing R-equol, and methods for their making
Issued: 3 November 2015
Assignee: Sanitarium (50%), Cincinnati Children's Hospital​ (United States, 50%)
Description: This patent covers​ R-equol, an intestinally derived metabolite of the soy isoflavone daidzein. R-equol may be useful in enhancing the efficacy of soy diets. 

US Patent 9,169,495

Title: Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells
Issued: 27 October 2015
Assignee: EnGeneIC
Description: This patent covers​ methods to deliver EnGeneIC's minicells into non-phagocytic cells, such as breast cancer cells.

US Patent 9,169,329

Title: Antibodies directed to the receptor tyrosine kinase c-Met
Issued: 27 October 2015
Assignee: Monash University (50%), Ludwig Institute for Cancer Research (US, 50%)
Description: This patent covers​ antibodies to the cancer target c-Met.

US Patent 9,169,211

Title: 8-hydroxy quinoline derivatives
Issued: 27 October 2015
Assignee: Prana Biotechnology (ASX: PBT)
Description: This patent covers​ a suite of metal-protein attenuating compounds useful in treating Alzheimer's.

US Patent 9,168,302

Title: Reduction of side effects from aromatase inhibitors used for treating breast cancer
Issued: 27 October 2015
Assignee: Chavah Pty Ltd 
Description: This patent covers​ the use of testosterone and anastrozole to reduce mammographic breast density, improving the ability to detect breast cancer with mammograms.

US Patent 9,168,216

Title: Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
Issued: 27 October 2015
Assignee: Phosphagenics (ASX: POH)
Description: This patent covers​ phosphate derivatives to improve transdermal drug delivery.

US Patent 9,163,081

Title: Antibody recognizing C-domain of midkine
Issued: 20 October 2015
Assignee: Cellmid (ASX: CDY)
Description: This patent covers​ antibodies to a cancer and inflammation target called midkine.

US Patent 9,163,029

Title: Substituted imidazo[1,2-a]pyrrolo[1,2-d]pyrazines for treating respiratory syncytial virus infections
Issued: 20 October 2015
Assignee: Biota
Description: This patent covers​ small molecules for the treatment of RSV infection.

US Patent 9,163,018

Title: Method of treatment of age-related macular degeneration (AMD)
Issued: 20 October 2015
Assignee:  Prana Biotechnology (ASX: PBT)
Description: This patent covers​ a suite of metal-protein attenuating compounds useful in treating AMD.

US Patent 9,162,985

Title: Salts and solvates of a tetrahydroisoquinoline derivative
Issued: 20 October 2015
Assignee: Spinifex Pharmaceuticals
Description: This patent covers​ a suite of angiotensin II type 2 receptor antagonists.

US Patent 9,161,923​

Title: Composition for prevention and treatment of contact lens papillary conjunctivitis and allergic eye disease​
Issued: 20 October 2015
Assignee: Brian Holden Vision Institute
Description: This patent covers​ a contact lens formulation containing Dexpanthenol to prevent conjunctivitis.

US Patent 9,161,562

Title: Natural sweetener
Issued: 20 October 2015
Assignee: Horizon Science Pty Ltd (David Kannar and Barry Kitchen)
Description: This patent covers​ a molasses extract.

US Patent 9,157,054

Title: Device and method for preparing microparticles
Issued: 13 October 2015
Assignee: University of Queensland
Description: This patent covers​ a continuous method to produce microgel particles that can be used to encapsulate functional ingredients or drugs. 

US Patent 9,156,916

Title: Modulation of T helper cell-mediated immune responses ​
Issued: 13 October 2015
Assignee: University of Sydney (50%), Northern Sydney and Central Coast Area Health Service (50%)
Description: This patent covers​ the use of surface membrane IgD antagonists to suppress ​Th1 immune components.

US Patent 9,156,855

Title: Regulation of nitric oxide release and biofilm development​
Issued: 13 October 2015
Assignee: University of New South Wales (50%), University of Wollongong (50%)
Description: This patent covers​ the use of nitric oxide with and antimicrobial agents to disperse biofilms created byPseudomonas aeruginosa.

US Patent 9,150,621

Title: Mutant bacterial glycoproteins and uses thereof
​Issued: 6 October 2015
Assignee: University of Queensland
Description: This patent covers the use of bacteria as immunogens where certain glycoproteins have been  pulled off the bacteria.

US Patent 9,150,619

Title: Method of elicting or inducing an immune response
​Issued: 6 October 2015
Assignee: CSL Ltd (ASX: CSL) (50%), University of Melbourne (50%)
Description: This patent covers the use of CSL's Iscomatrix adjuvant for intra-lung delivery of vaccines.

US Patent 9,149,452

Title: Methods and compositions for promoting the neurological development of an infant
​Issued: 6 October 2015
Assignee: Women's & Children's Health Research Institute
Description: This patent covers the use fatty acids high in docosahexaenoic acid as brain food for babies.

US Patent 9,145,375

Title: Quinazolinone compounds
​Issued: 29 September 2015
Assignee: ​Prana Biotechnology (ASX: PBT)
Description: This patent covers the use of quinazolinone compounds for the treatment of Parkinson's Disease.

US Patent 9,139,879

Title: TAM receptors and TAM receptor ligands in detection and modulation of neuropathological disease
​Issued: 22 September 2015
Assignee: Florey Institute of Neuroscience and Mental Health
Description: This patent covers the use of TAM receptors for the treatment of Multiple Sclerosis.

US Patent 9,134,311

Title: Methods and compositions for treating and preventing malaria using an invasion ligand directed to a protease-resistant receptor
​Issued: 15 September 2015
Assignee: Walter and Eliza Hall Institute
Description: This patent covers a potential malaria vaccine based on a ligand which the malaria parasite uses to enter into erythrocytes.

US Patent 9,133,188

Title: Methods for preparing naphthyridines
​Issued: 15 September 2015
Assignee: Bionomics (ASX: BNO)
Description: This patent covers methods to scale-up production of Bionomics's anti-anxiolytic drug.

US Patent 9,131,681

Title: Particles comprising a releasable dopant therein
​Issued: 15 September 2015
Assignee: ​Australian Nuclear Science & Technology Organisation

Description: This patent covers a method to include a dopant, such as a hydrophobic material, into solid or gel particles without the use of toxic solvents.

US Patent 9,127,130

Title: Polylysine dendrimer contrast agent
​Issued: 8 September 2015
Assignee: Starpharma (ASX: SPL) (50%), Baker IDI Heart And Diabetes Institute (50%)

Description: This patent covers a contrast agent made out of Starpharma's dendrimers.

US Patent 9,127,057

Title: Anti-IL-23 heterodimer specific antibodies
​Issued: 8 September 2015
Assignee: ​Teva Pharmaceuticals Australia

Description: This patent covers antibodies to Interleukin 23, an autoimmune disease target.

US Patent 9,125,943

Title: Reconstituted HDL formulation
​Issued: 8 September 2015
Assignee: ​CSL Ltd (ASX: CSL)
Description: This patent covers CSL's reconstituted HDL, useful for the treatment of Acute Coronary Syndrome.

US Patent 9,125,853

Title: Treatment or prevention of infection
​Issued: 8 September 2015
Assignee: ​Oral Health CRC
Description: This patent covers a vaccine against Porphyromonas gingivalis.

US Patent 9,122,778

Title: Methods of treating diseases
​Issued: 1 September 2015
Assignee: Biotempus
Description: This patent covers the use of immune system cycles for optimal chemotherapy.

US Patent 9,120,775

Title: Viral polymerase inhibitors
​​Issued: 1 September 2015
Assignee: Biota
Description: This patent covers small molecule inhibitors of HCV polymerase.

US Patent 9,119,833

Title: Administration of relaxin to treat nephrogenic diseases of water imbalance involving ​acquaporin-4
​Issued: 1 September 2015
Assignee: University of Melbourne (50%), University of Florida (US, 50%)
Description: This patent covers the use of relaxin to treat kidney disease.

US Patent 9,119,818

​Title: Use of angiogenin or angiogenin agonists for treating diseases and disorders
​Issued: 1 September 2015
Assignee:Murray Goulburn Co-Operative (50%), Agriculture Victoria Services (50%) ​​
Description: This patent covers milk enriched for angiogenin, a peptide with anti-inflammatory and anti-microbial properties.

US Patent 9,119,805

Title: Therapy and prevention of problem drinking
​Issued: 1 September 2015
Assignee: University of Sydney
Description: This patent covers the use of oxytocin in treating alcohol addiction.

US Patent 9,119,394

Title: Anti-microbial polymers and their compositions 
​Issued: 1 September 2015
Assignee:​ Recce (ASX: RCE)
Description: This patent covers polymers of acrolein for the treatment of bacterial infections.

US Patent 9,115,363

Title: Gene expression and eradication system in Helicobacter pylori
Issued: 25 August 2015
Assignee: Ondek
Description: This patent covers the use of H. pylori as a tool for ​biological delivery vehicle for peptides 

US Patent 9,110,061

Title: Use of amino acid sequences from mycobacterium tuberculosis or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom
Issued: 18 August 2015
Assignee: Cellestis
Description: This patent covers genes from M. tuberculosis used as a tuberculosis diagnostic.

US Patent 9,109,040

Title: Treatment and prevention of malaria
Issued: 18 August 2015
Assignee: Walter and Eliza Hall Institute
Description: This patent covers ligand which the malaria parasite uses to enter into erythrocytes.

US Patent 9,107,811

Title: Composition for treating skin lesions
Issued: 18 August 2015
Assignee: Sci-Chem International Pty Ltd
Description: This patent covers a combination of copper and Hypericum perforatum extract to treat skin lesions.

US Patent 9,101,732

Title: Drug-delivery accessory for an implantable medical device
Issued: 11 August 2015
Assignee: Cochlear (ASX: COH)
Description: This patent covers a device to allow neural drug delivery alongside implantation of a cochlear implant.

US Patent 9,101,650

Title: Treatment of bone marrow edema (oedema) with polysulfated polysaccharides
Issued: 11 August 2015
Assignee: ​Paradigm Biopharma (ASX: PAR)
Description: This patent covers the use of polysulphate sodium in treating bone marrow edema.

US Patent 9,095,587

Title: Methods and compositions for improved nerve conduction velocity​
Issued: 4 August 2015
Assignee: ​Spinifex Pharmaceuticals
Description: This patent covers the use of an angiotensin II type 2 receptor antagonist to improve nerve conduction velocities.

US Patent 9,095,524

Title: ​Customized compositions and uses thereof
Issued: 4 August 2015
Assignee: Bond University
Description: This patent covers a three-dimensional nanofiber webbing used in the treatment of AMD.

US Patent 9,095,519

Title: Dosage form containing two or more active pharmaceutical ingredients in different physical forms
Issued: 4 August 2015
Assignee: Alphapharm Pty Ltd
Description: This patent covers a method of combining APIs in a drug formulation for that the two APIs can be easily separated for analytical testing.

US Patent 9,090,706

Title: Fibronectin: growth factor chimeras​
Issued: 28 July 2015
Assignee: Queensland University of Technology
Description: This patent covers combinations of fibronectin and growth factors such as IGF-I, useful in tissue repair.

US Patent 9,089,508

Title: Method of transfection and compositions therefor
Issued: 28 July 2015
Assignee: University of Melbourne
Description: This patent covers the use of bacterial cell wall lipid called Pam2Cys for targeted delivery of molecules to cells expressing toll-like receptors

US Patent 9,085,770

Title: Delivery of dsRNA to arthropods
Issued: 21 July 2015
Assignee: ​Commonwealth Scientific and Industrial Research Organisation
Description: This patent covers a gene silencing technique

US Patent 9,085,628

Title: Antibody molecule for human GM-CSF receptor alpha
Issued: 21 July 2015
Assignee: CSL Ltd (ASX: CSL) (50%), Medimmune (US, 50%)
Description: This patent covers antibodies to GM-CSF-alpha, useful in treating autoimmune diseases.

US Patent 9,084,827

Title: Biodegradable polyurethane/urea compositions
Issued: 21 July 2015
Assignee: Polynovo (ASX: PNV)
Description: This patent covers a ​biodegradable polymer for use in tissue repair.

US Patent 9,084,770

Title: Modulation of insulin like growth factor I receptor expression in cancer
Issued: 21 July 2015
Assignee: Antisense Therapeutics (ASX: ANP)
Description: This patent covers the use of IGF-I receptor antisense oligonucleotides in the treatment of cancer.

US Patent 9,079,967

Title: Modified chaperonin 10​
Issued: 14 July 2015
Assignee: Invion (ASX: IVX)
Description: This patent covers chaperonin 10 polypeptides, useful for activating Toll-Like Receptors.

US Patent 9,079,950

Title: Modified Hepatitis C virus proteins
Issued: 14 July 2015
Assignee: ​Burnet Institute
Description: This patent covers a modified HCV E2 protein that allows better structural and functional studies of HCV.

US Patent 9,078,845

Title: Anti-microbial agent​
Issued: 14 July 2015
Assignee: Kayban Pty Ltd
Description: This patent covers a combination of alpha-linolenic acid and tea tree oil useful as an anti-microbial.

US Patent 9,078,816

Title: Buccal, polar and non-polar spray containing ondansetron
Issued: 14 July 2015
Assignee: Suda Ltd (ASX: SUD)
Description: This patent covers a buccal spray for the delivery of the nausea drug ondansetron.

US Patent 9,078,810

Title: Transdermal delivery system​
Issued: 14 July 2015
Assignee: Acrux (ASX: ACR)
Description: This patent covers a transdermal drug delivery penetration enhancer based on salicylic acid and polyethylene glycol.

US Patent 9,073,997

Title: Growth factor antagonists for organ transplant alloimmunity and arteriosclerosis​
Issued: 7 July 2015
Assignee: ​Opthea (ASX: OPT)
Description: This patent covers antagonosts to VEGFR-3.

US Patent 9,066,982

Title: Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells
Issued: 30 June 2015
Assignee: ​​ EnGeneIC
Description: This patent covers bacterially derived 'minicells' containing functional nucleic acids for gene therapy.

US Patent 9,066,919

Title: Hyaluronan as a chemo-sensitizer in the treatment of cancer
Issued: 30 June 2015
Assignee: ​Alchemia (ASX: ACL)
Description: This patent covers the use of hyaluronic acid to better target cancer drugs.

US Patent 9,066,526

Title: Allergy treatment using acid treated aqueous whey protein extract​
Issued: 30 June 2015
Assignee: ​Dairy Australia
Description: This patent covers acid treated whey protein as a treatment for allergies.

US Patent 9,063,155

Title: Immunotherapeutic method of treating neoplastic conditions
Issued: 23 June 2015
Assignee: ​Medvet Science Pty Ltd
Description: This patent covers antibodies to the La antigen, indicative of an apoptotic cell.

US Patent 9,062,288

Title: Therapeutic methods using adipose tissue-derived cell suspensions comprising adipocytes
Issued: 23 June 2015
Assignee: ​Regeneus (ASX: RGS)
Description: This patent covers adipose-derived mesenchymal stem cells for use in treating inflammatory disorders in animals.

US Patent 9,062,118

Title: J-superfamily conotoxin peptides
Issued: 23 June 2015
Assignee: University of Queensland (33%), University of Utah (US 33%), ​Max Planck Society (Germany 33%)
Description: This patent covers conotoxins potential useful in disorders involving ion channels.

US Patent 9,062,013

Title: Positive allosteric modulators of the alpha.7 nicotinic acetylcholine receptor and uses thereof​
Issued: 23 June 2015
Assignee: Bionomics (ASX: BNO)
Description: This patent covers small molecules that target the nicotinic acetylcholine receptor, potentially useful in treating Alcheimer's and schizophrenia.

US Patent 9,062,013

Title: Chimeric relaxin polypeptides comprising an A and B chain derived from different relaxin family peptides
Issued: 16 June 2015
Assignee:  Florey Institute of Neuroscience and Mental Health
Description: This patent covers peptide derived from relaxin useful in treatment of blood pressure and kidney issues.

US Patent 9,051,551

Title: Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
Issued: 9 June 2015
Assignee: University of Western Australia
Description: This patent covers the use of a microRNA called miR-7 to sensitive cancer cells to treatment tyrosine kinase inhibitors such as Erlotinib.

US Patent 9,051,369

Title: Avian cytokines and genetic sequences encoding same​
Issued: 9 June 2015
Assignee: Commonwealth Scientific and Industrial Research Organisation
Description: This patent covers chicken interferon gamma for treating avian disease.

US Patent 9,045,475

Title: Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Issued: 2 June 2015
Assignee: Walter and Eliza Hall Institute (33%), AbbVie (US, 33%), Genentech (US, 33%)
Description: This patent covers small molecules that inhibit ​anti-apoptotic Bcl-2 proteins.

US Patent 9,045,452

Title: Antimicrobial and radioprotective compounds​
Issued: 2 June 2015
Assignee: BioDiem
Description: This patent covers​ various substituted nitrostyrene compounds with anti-microbial as well as radioprotective qualities.

US Patent 9,044,489

Title: Medicinal compositions containing honey​
Issued: 2 June 2015
Assignee: Medihoney Pty Ltd
Description: This patent covers honey with ​non-peroxide antibacterial activity.

US Patent 9,040,503

Title: Medicinal carbohydrates for treatment of respiratory conditions
Issued: 26 May 2015
Assignee: Aus Bio Ltd
Description: This patent covers glycoproteins to restore sialylglycoconjugates on the surface of the respiratory cell.

US Patent 9,035,028

Title: Temperature sensitive conjugate compositions​
Issued: 19 May 2015
Assignee: Baker IDI Heart and Diabetes Institute (50%), Emory University (US, 50%)
Description: This patent covers a temperature sensitive polymer conjugated to an single-chain antibidy to integrin GPIIb/IIIa to preserve platelet function during cardiopulmonary bypass.

US Patent 9,034,381

Title: Process to control particle size
Issued: 19 May 2015
Assignee: Alphapharm Pty Ltd
Description: This patent covers methods for maintaining particle size consistency in a drug formulation.

US Patent 9,034,378

Title: Biodegradable polyurethane and polyurethane ureas
Issued: 19 May 2015
Assignee: PolyNovo (ASX: PNV)
Description: This patent covers a ​biodegradable polymer material.

US Patent 9,023,892

Title: Antimicrobial compounds
Issued: 5 May 2015
Assignee: Ramiz Boulos
Description: This patent covers aryl compound with antibiotic properties.

US Patent 9,023,863

Title: Fatty acid pharmaceutical foam
Issued: 5 May 2015
Assignee: Stiefel Research Australia
Description: This patent covers a transdermal foam for drug delivery.

US Patent 9,023,799

Title: Method to reduce loss of cardiac function following ischemia/reperfusion
Issued: 5 May 2015
Assignee: ​Cellmid (ASX: CDY)
Description: This patent covers the use of midkine to treat reperfusion injury.

US Patent 9,018,247

Title: Compositions and products containing S-equol, and methods for their making
Issued: 28 April 2015
Assignee: Sanitarium (50%); Cincinnati Children's Hospital​ (United States, 50%)
Description: This patent covers S-equol, an intestinally derived metabolite of the soy isoflavone daidzein. S-equol may be useful in enhancing the efficacy of soy diets. ​

US Patent 9,018,207

Title: Method of treatment or prophylaxis
Issued: 28 April 2015
Assignee: Spinifex Pharmaceuticals
Description: This patent covers​ a suite of angiotensin II type 2 receptor antagonists.

US Patent 9,018,168

Title: Therapeutic method for treating congestive heart failure
Issued: 28 April 2015
Assignee: Madeleine Pharmaceuticals
Description: This patent covers a derivative of atrial natriuretic peptide for the treatment of heart failure.

US Patent 9,017,697

Title: Compositions and methods for modulating immune responses​
Issued: 28 April 2015
Assignee: University of Queensland
Description: This patent covers an NF-κB inhibitor.

US Patent 9,017,643

Title: Particles comprising a releasable dopant therein
Issued: 28 April 2015
Assignee: Australian Nuclear Science & Technology Organisation
Description: This patent covers a method to include a dopant, such as a hydrophobic material, into solid or gel particles without the use of toxic solvents.

US Patent 9,011,878

Title: Vaccine strains of Brachyspira hyodysenteriae
Issued: 21 April 2015
Assignee: Spirogene Pty Ltd
Description: This patent covers live vaccine strains for the intestinal spirochaete B. hyodysenteriae.

US Patent 9,006,397

Title: FN14 binding proteins and uses thereof
Issued: 14 April 2015
Assignee: TransBio
Description: This patent covers antibodies to Fibroblast Growth Factor Inducible 14 , relevant in the treatment of cachexia.

US Patent 9,006,284

Title: Combination therapy for treating proliferative diseases​
Issued: 14 April 2015
Assignee: Bionomics (ASX: BNO)
Description: This patent covers the combination of ​a tubulin polymerisation inhibitor and an mTOR inhibitor for the treatment of cancer.

US Patent 9,006,200

Title: MicroRNA-based approach to treating malignant pleural mesothelioma
Issued: 14 April 2015
Assignee: Asbestos Diseases Research Institute
Description: This patent covers microRNA mimics, corresponding to the miR-15/107 family potentially useful in the treatment of mesothelioma.

US Patent 8,999,920

Title: Reconstituted high density lipoprotein formulation and production method thereof​
Issued: 7 April 2015
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers CSL's reconstituted HDL, useful for the treatment of Acute Coronary Syndrome.

US Patent 8,999,353

Title: Method of eliciting an immune response against pandemic influenza virus
Issued: 7 April 2015
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers the use of CSL's Iscomatrix adjuvant in creating an H5N1 virus.

US Patent 8,993,635

Title: Method of increasing or maintaining the reproductive performance of sows
Issued: 31 March 2015
Assignee: Pork CRC
Description: This patent covers the use of ractopamine in maintaining the reproductive performance of sows.

US Patent 8,993,520

Title: Method and composition for transdermal drug delivery​
Issued: 31 March 2015
Assignee: Acrux (ASX: ACR)
Description: This patent covers the use octyl salicylate as a ​penetration enhancer.

US Patent 8,992,986

Title: Controlled release of biological entities
Issued: 31 March 2015
Assignee: Australian Nuclear Science & Technology Organisation
Description: This patent covers a ceramic encapsulant used for drug delivery.

US Patent 8,992,982

Title: Formulation of indomethacin
Issued: 31 March 2015
Assignee: iCeutica
Description: This patent covers a formulation of indomethacin using a drug milling process for smaller particle size.

US Patent 8,992,935

Title: Means of controlling infection persistence of Helicobacter pylori 
Issued: 31 March 2015
Assignee: Ondek
Description: This patent covers a genetically modified H. pylori as a vaccine strain.

US Patent 8,986,700

Title: Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes
Issued: 24 March 2015
Assignee: Queensland Institute of Medical Research
Description: This patent covers lipopeptides for making self-adjuvanting peptide vaccines.

US Patent 8,980,914

Title: Therapeutic agent for chronic obstructive pulmonary disease and method for treatment for chronic obstructive pulmonary disease with the same​
Issued: 17 March 2015
Assignee: Mariposa Health
Description: This patent covers 7-aminoquinolinone derivative for the treatment of COPD.

US Patent 8,975,278

Title: 8-hydroxy quinoline derivatives​
Issued: 10 March 2015
Assignee: Prana Biotechnology (ASX: PBT)
Description: This patent covers a suite of metal-protein attenuating compounds useful in treating Alzheimer's.

US Patent 8,975,245

Title: Anaesthetic formulation
Issued: 10 March 2015
Assignee: Drawbridge Pharmaceuticals
Description: This patent a clear aqueous solution of the neuroactive steroid anaesthetic Alphaxalone.

US Patent 8,974,803

Title: Injectable biomaterials
Issued: 10 March 2015
Assignee: University of Sydney
Description: This patent covers injectable ​tropoelastin for tissue repair.

US Patent 8,968,731

Title: Treatment of uveitis
Issued: 3 March 2015
Assignee: CSL Ltd (ASX: CSL)
Description: This patent covers antibodies to G-CSF Receptor for the treatment of uveitis. 

US Patent 8,962,830

Title: Protein kinase inhibitors and methods of treatment
Issued: 24 February 2015
Assignee: ​Walter and Eliza Hall Institute
Description: This patent covers  Src family kinase inhibitors.

US Patent 8,962,801

Title: Neisseria porin proteins
Issued: 24 February 2015
Assignee: Griffith University
Description: This patent covers  proteins from Neisseria meningitidis suitable for a vaccine construct.

US Patent 8,962,649

Title: Multidose package, course and method of treatment for delivering predetermined multiple doses of a pharmaceutical
Issued: 24 February 2015
Assignee: iNova Pharmaceuticals
Description: This patent covers  the packaging for an ​imiquimod formulation.

US Patent 8,960,128

Title: Topical anesthetic composition
Issued: 24 February 2015
Assignee: Animal Ethics Pty Ltd
Description: This patent covers  a topical anesthetic for applications such as mulesing of sheep.

US Patent 8,957,099

Title: Treatment of ADHD
Issued: 17 February 2015
Assignee: Gosforth Clinic (Dr Philip Bird)
Description: This patent covers the use of sodium valproate in the treatment of ADHD.

US Patent 8,956,864

Title: Bacterially derived intact minicells that encompass plasmid free functional nucleic acid for in vivo delivery to mammalian cells
Issued: 17 February 2015
Assignee: EnGeneIC
Description: This patent covers 'minicells' for the delivery of nucleic acid into cells.

US Patent 8,951,543

Title: Nano silver--zinc oxide composition
Issued: 10 February 2015
Assignee: Polymers CRC
Description: This patent covers a silver-zinc formation with anti-microbial properties.

US Patent 8,946,381

Title: Compositions and uses thereof for the treatment of wounds
Issued: 3 February 2015
Assignee: Phylogica (ASX: PYC), McComb Foundation.
Description: This patent covers an AP-1 signaling inhibitor for the treatment of wounds.

US Patent 8,946,146

Title: Method for modulating appetite
Issued: 3 February 2015
Assignee: St Vincent's Hospital Sydney.
Description: This patent covers an inhibitor of macrophage inhibitory cytokine-1 (MIC-1) for weight loss. 

US Patent 8,945,551

Title: Biopolymer hybrid gel-depot delivery system
Issued: 3 February 2015
Assignee: Polymers CRC
Description: This patent covers a biopolymer gel used for controlled release of drugs.

US Patent 8,940,695

Title: Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
Issued: 27 January 2015
Assignee: Opthea (ASX: OPT)
Description: This patent covers the cancer target VEGFR-3 as well as antibodies to it.

US Patent 8,939,932

Title: Inactivation of papillomavirus
Issued: 27 January 2015
Assignee:​ Dr Jenny McCloskey
Description: This patent covers a device for delivery of a viral inactivation agent in HPV infection.

US Patent 8,937,052

Title: Therapeutic protocols using hyaluronan
Issued: 20 January 2015
Assignee:​ ​Alchemia (ASX: ACL)
Description: This patent covers the use of hyaluron as a vehicle for targeted delivery of cancer drugs.

US Patent 8,933,092

Title: Methods and compositions comprising sequential administration opioid receptor agonists
Issued: 13 January 2015
Assignee:​ ​QRXPharma
Description: This patent covers the combination of morphine and oxycodone for pain management.

US Patent 8,933,033

Title: Chaperonin 10 variants
Issued: 13 January 2015
Assignee:​ ​ Invion (ASX: IVX)
Description: This patent covers chaperonin 10 polypeptides, useful for activating Toll-Like Receptors.

US Patent 8,933,027

Title: Method of treating a disease or condition characterised by aberrant epithelial cell proliferation
Issued: 13 January 2015
Assignee:​ ​Queensland University of Technology
Description: This patent covers combinations of fibronectin and IGF-I, useful in tissue repair.

US Patent 8,932,588

Title: Treatment of cancer involving mutated KRAS or BRAF genes
Issued: 13 January 2015
Assignee:​ ​Teva Pharmaceuticals Australia
Description: This patent covers a monoclonal antibody to colon cancer where the cancer has KRAS and BRAF mutants.

US Patent 8,927,575

Title: Salts and solvates of a tetrahydroisoquinoline derivative  
Issued: 6 January 2015
Assignee:​ ​​Spinifex Pharmaceuticals
Description: This patent covers angiotensin receptor blockers

US Patent 8,927,565

Title: Compositions for veterinary and medical applications
Issued: 6 January 2015
Assignee:​ ​Aus Bio Ltd
Description: This patent covers the use of berberine chloride in the treatment of gastrointestinal disorders

US Patent 8,927,503

Title: Modulations of protease activated receptors
Issued: 6 January 2015
Assignee:​ ​University of Queensland
Description: This patent covers antagonists to a GPCR called Protease activated receptor-2.

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